Hi Yacine, I suppose you lose the live file sharing features of the online version, as well as the immediate updates, whether you want them or not, but then you can get that with the desktop as well. My system here for Visual Studio work rebooted and installed updates while I was sitting here! Warning? Non! But with the desktop version you get a real 365 day per year capability, not just when the servers decide to give you access, (it isn't referred to jokingly as Office 363-- for no reason) and of course all work is kept on site, not in some cloud somewhere where who knows who might be able to look at it.
Do you get online and desktop versions in Plan 2?
Me? Cloud? Never! I'm not a luddite, just sensible!