I'm ready to pull my hair out and hoping someone can assist.
1) I installed Visio 2007 onto my C: drive from our corporate software download site- this was a clean download on a new system.
2) Everytime I would launch Visio, a MS pop-up window would prompt me to visit MS to download an 'enhancement to Visio'. After ignoring the pop-up for about 4 weeks, I finally clicked the link and downloaded the 'patch' or 'upgrade' or whatever it was -- I DO know it was from a microsoft URL.
3) Now, when I launch Visio, EVERY .exe file on my D: launches (c: not affected).
4) I ran Norton anti-virus and spyware scans, then I ran MS 'Defender' - Neither found any virus'.
5) I uninstalled Visio from Add/Remove programs and reinstalled Visio 2007 -- issue continued (note the MS Visio enhanced functionality 'pop-up' prompt did not return after reinstall).
6) I can launch Visio in safe mode with no issue (hold down ctrl key on start up).
7) Because the issue doesn't exist if I'm in safe mode, to troubleshoot I went through every Add-On available from Tools --> Add-Ons, and ran them separately. The issue was reproduced when an Adobe Acrobat conversion add-on launched (didn't write down the name).

As FYI - there are no "macros" showing under the macro options.
9) I uninstalled Adobe Acrobat, uninstalled Visio -- rebooted, then reinstalled both apps again... yes, the problem STILL exists.
10) As of today, working in MS Word 2003, when I SINGLE click to select a Visio diagram, it triggers the same response (all .exe's from D: launch) EVEN though I already have a Visio 2007 session running.
11) I have gone into Tools --> Trust Center and disabled Active X and Macro options, however the "Add-Ins" option to "disable all Application Add-in (may impair functionality)" will not hold my checkbox option after I hit "OK"... when I go back into the window, it's always unchecked again -- nevertheless, the settings which did stick had no affect on the issue I'm having.
I've spent a few hours on MS website looking for support documents, but didn't find this issue. I did find something remotely similar related to Adobe, but I unistalled and reinstalled, and currently the adobe icon for conversion is not present in my tool bar icons as it was before.
My internal help is just telling me to refresh my profile, but no one knows the issue -- feels like that's not root causing.
Has anyone seen this issue before? Does anyone know what could be causing this and what I can do to resolve?
Thank you for your time,
Soon to be known as "Baldy" ;-)