OK. Latest updates.
I am now of the opinion that VoJo was correct so I have decided to break the file up into chapters. VoJo's wisdom wins over my stubborn streak, so thank you (and take a bow javascript:void(0)

.
Back Ups. Oh, yes! 4 local and one to my website server (been burnt oh so many times before).
Creating HTML (the original project) - have been running the Sandrila alternative Web page creator on a copy of my original file on my laptop...since December 23rd! 4 days later, it's between a third and halfway through creating the .png files.
Casewise conversions. Again I had problems converting the original large file to Casewise (This tool now has a Visio front-end, but I don't have a copy of that), but these problems actually appear down to data errors in the diagrams (spelling mistakes, additional spaces at the end of text strings...that sort of thing). Breaking the file up allowed me to correct these errors and the smaller files seem to be uploading/converting OK.
I'm tempted to go back and error correct the original file and try again (that stubborn streak of mine again), but if I can build hyper linked HTML pages either through Casewise or on the new, smaller "chapter" files, it would simply be an academic exercise.
Thanks, again to all the other suggestions - I'll try and respond a little quicker next time.